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PARP1-IN-6

Names

[ CAS No. ]:
1654735-36-0

[ Name ]:
PARP1-IN-6

Biological Activity

[Description]:

PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC50 values of 0.94 and 0.48 μM, respectively.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[References]

[1]. Zheng L, et al. Discovery of a Dual Tubulin and Poly(ADP-Ribose) Polymerase-1 Inhibitor by Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, and Biological Evaluation. J Med Chem. 2021 Nov 11;64(21):15702-15715.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₁FN₂O

[ Molecular Weight ]:
266.27

Related Compounds