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Trifluoperazine N-β-D-Glucuronide

Names

[ CAS No. ]:
165602-90-4

[ Name ]:
Trifluoperazine N-β-D-Glucuronide

[Synonym ]:
Trifluoperazine N-Glucuronide
1-|A-D-Glucopyranuronosyl-1-methyl-4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]piperazinium Inner Salt
Trifluoperazine N-|A-D-GlucuronideDISCONTINUED
Trifluoperazine glucuronide

Biological Activity

[Description]:

Trifluoperazine N-Glucuronide (UGT1A4), as one of the human UGT1A isoforms, is expressed in the liver. Trifluoperazine N-Glucuronide catalyzes the imipramine and trifluoperazine Nglucuronide formation[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Trifluoperazine N-Glucuronide (1~10 μg; HEK293 cells) expression levels is 0.14 unit/mg protein[1]. Trifluoperazine N-Glucuronide coexpression affects the activity of human UGT1A9. The imipramine N-glucuronide formation by the single expression system of trifluoperazine N-Glucuronide follows the Michaelis-Menten equation. Trifluoperazine N-Glucuronide interacts with the human UGT1A1 and UGT1A6, affecting the enzymatic activities[1].

[References]

[1]. Fujiwara R, et al. Interactions between human UGT1A1, UGT1A4, and UGT1A6 affect their enzymatic activities. Drug Metab Dispos. 2007;35(10):1781-1787

Chemical & Physical Properties

[ Molecular Formula ]:
C27H32F3N3O6S

[ Molecular Weight ]:
583.62000

[ Exact Mass ]:
583.19600

[ PSA ]:
141.83000

[ LogP ]:
0.97960

Synthetic Route

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Related Compounds