Glycochenodeoxycholic acid sodium

Names

[ Name ]:
Glycochenodeoxycholic acid sodium

[Synonym ]:
Sodium glycochenodeoxycholate
3α,7α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide sodium salt
Sodium {[(3α,5β,7α,8ξ)-3,7-dihydroxy-24-oxocholan-24-yl]amino}acetate
Glycine, N-((3α,5β,7α)-3,7-dihydroxy-24-oxocholan-24-yl)-, monosodium salt
N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt
Glycine, N-[(3α,5β,7α,8ξ)-3,7-dihydroxy-24-oxocholan-24-yl]-, sodium salt (1:1)
Glycochenodeoxycholic acid sodium salt

Biological Activity

[Description]:

Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Liang S, et al. Effect of quercetin 7-rhamnoside on glycochenodeoxycholic acid-induced L-02 human normal livercell apoptosis. Int J Mol Med. 2013 Aug;32(2):323-30.

[2]. Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27.

Chemical & Physical Properties

[ Boiling Point ]:
655.6ºC at 760mmHg

[ Molecular Formula ]:
C₂₆H₄₂NNaO₅

[ Molecular Weight ]:
471.605

[ Flash Point ]:
350.3ºC

[ Exact Mass ]:
471.296082

[ PSA ]:
109.69000

[ LogP ]:
2.65030

[ Vapour Pressure ]:
5.74E-20mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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