Indisulam

Names

[ Name ]:
Indisulam

[Synonym ]:
E7070
Indisulam (IND)
1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-
indisulam
N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
N-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
Indisulam (USAN/INN)
1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl)

Biological Activity

[Description]:

Indisulam (E 7070) is a carbonic anhydrase inhibitor and a G1-targeting agent. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 (CDK2) and cyclin E. Shows anti-tumor activity in human colon and lung cancer cells[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Carbonic anhydrase[1].

[References]

[1]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82.

[2]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
668.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₂ClN₃O₄S₂

[ Molecular Weight ]:
385.846

[ Flash Point ]:
358.4±34.3 °C

[ Exact Mass ]:
384.995789

[ PSA ]:
138.88000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.731

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%