Sympatol {Tartrate}

Names

[ Name ]:
Sympatol {Tartrate}

[Synonym ]:
Corvasymton {Tartrate}
Sympathol {Tartrate}
DL-4-HYDROXY-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL D-TARTRATE
EINECS 240-647-8
(±)-1-(4-Hydroxyphenyl)-2-methylaminoethanol tartrate
4-[1-hydroxy-2-(methylamino)ethyl]phenol 2,3-dihydroxybutanedioate (1:1)
1-(4-Hydroxyphenyl)-2-(methylamino)ethanol tartrate
2,3-dihydroxybutanedioic acid,4-[1-hydroxy-2-(methylamino)ethyl]phenol
Simpadren {Tartrate}
Sympatol {Tartrate}
Synephrine tartrate
4-[1-Hydroxy-2-(methylamino)ethyl]phenol 2,3-dihydroxysuccinate (1:1)
MFCD00151120
Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, 2,3-dihydroxybutanedioate (1:1) (salt)

Biological Activity

[Description]:

Synephrine (Oxedrine) hemitartrate, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hemitartrate is a sympathomimetic compound and can be used for weight loss[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[In Vivo]

Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine[2]. Animal Model: Portal vein ligation (PVL) or bile duct ligation (BDL) rats[2]. Dosage: 1 mg/kg per 12 hours Administration: Oral gavage; for 8 days Result: The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced.

[References]

[1]. Thomas JE, et al. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009;36(6):586-90.

[2]. Huang YT, et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb;85(2):183-8.

Chemical & Physical Properties

[ Density]:
1.159 g/cm3

[ Boiling Point ]:
823.3ºC at 760 mmHg

[ Melting Point ]:
184 °C

[ Molecular Formula ]:
C₂₂H₃₂N₂O₁₀

[ Molecular Weight ]:
317.292

[ Flash Point ]:
451.7ºC

[ Exact Mass ]:
317.111053

[ PSA ]:
220.04000

[ Vapour Pressure ]:
1.08E-28mmHg at 25°C

[ Index of Refraction ]:
13 ° (C=5, H2O)

MSDS

Click to get detail MSDS

Safety Information

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39