2,4',5-Trichlorobiphenyl
Names
[ CAS No. ]:
16606-02-3
[ Name ]:
2,4',5-Trichlorobiphenyl
[Synonym ]:
1,4-dichloro-2-(4-chlorophenyl)benzene
MFCD00078742
1,1'-Biphenyl, 2,4',5-trichloro-
2,4',5-Trichlorobiphenyl
2,4',5-Trichlorobiphényl
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
331.5±27.0 °C at 760 mmHg
[ Melting Point ]:
67℃
[ Molecular Formula ]:
C12H7Cl3
[ Molecular Weight ]:
257.543
[ Flash Point ]:
227.3±19.3 °C
[ Exact Mass ]:
255.961334
[ LogP ]:
5.52
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.604
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DV8810000
- CHEMICAL NAME :
- Biphenyl, 2,4',5-trichloro-
- CAS REGISTRY NUMBER :
- 16606-02-3
- BEILSTEIN REFERENCE NO. :
- 1961529
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C12-H7-Cl3
- MOLECULAR WEIGHT :
- 257.54
- WISWESSER LINE NOTATION :
- GR BG DR BG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg/3D-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,94,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 21 mg/kg/84D-C
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Brain and Coverings - changes in brain weight Liver - changes in liver weight
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,629,1977 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 120 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 42,323,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 78 mg/kg
- SEX/DURATION :
- female 5-21 day(s) after conception lactating female 22 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 42,275,1978 *** REVIEWS *** TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 24,173,1978
Safety Information
[ Symbol ]:
GHS08, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H373-H410
[ Precautionary Statements ]:
P273-P391-P501
[ Hazard Codes ]:
N: Dangerous for the environment;
[ Risk Phrases ]:
R33
[ Safety Phrases ]:
S35
[ RIDADR ]:
UN 3432 9/PG 2
[ RTECS ]:
DV8810000
[ HS Code ]:
2903999090
Synthetic Route
Customs
[ HS Code ]: 2903999090
[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
Exp. Toxicol. Pathol. 49(3-4) , 289-93, (1997)
In the present paper we describe needle-shaped and granular cytoplasmic inclusions in the liver cells of mice and rats with experimental porphyria biochemically resembling human porphyria cutanea tard...
Alteration of regiospecificity in biphenyl dioxygenase by active-site engineering.J. Bacteriol. 184(13) , 3682-8, (2002)
Biphenyl dioxygenase (Bph Dox) is responsible for the initial dioxygenation step during the metabolism of biphenyl. The large subunit (BphA1) of Bph Dox plays a crucial role in the determination of th...
Impacts of molt-inhibiting organochlorine compounds on epidermal ecdysteroid signaling in the fiddler crab, Uca pugilator, in vitro.Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 150(4) , 436-41, (2009)
Because of their chemical stability and lipophilicity, many organochlorine compounds (OCs) can readily accumulate in fatty tissues of crustaceans. Several OCs have been reported to inhibit crustacean ...