Fmoc-8-amino-3,6-dioxaoctanoic acid

Names

[ Name ]:
Fmoc-8-amino-3,6-dioxaoctanoic acid

[Synonym ]:
2,7,10-Trioxa-4-azadodecan-12-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-
[2-[2-(Fmoc-Amino)ethoxy]ethoxy]acetic acid
[2-[2-[(Fmoc-amino)ethoxy]ethoxy]acetic Acid
8-(Fmoc-amino)-3,6-dioxa-n-octanoic Acid
{2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-acetic acid
Fmoc-NH-PEG2-CH2COOH
MFCD01321015
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid
[2-[2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]acetic Acid
2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetic acid
8-[(9H-Fluoren-9-ylMethoxy)carbonylaMino]-3,6-dioxa-n-octanoic Acid
Fmoc-mini-PEG
Fmoc-AEEA

Biological Activity

[Description]:

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
631.4±45.0 °C at 760 mmHg

[ Melting Point ]:
90-92℃

[ Molecular Formula ]:
C₂₁H₂₃NO₆

[ Molecular Weight ]:
385.410

[ Flash Point ]:
335.6±28.7 °C

[ Exact Mass ]:
385.152527

[ PSA ]:
94.09000

[ LogP ]:
2.63

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Storage condition ]:
-15°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%