AZD 4407

Names

[ CAS No. ]:
166882-70-8

[ Name ]:
AZD 4407

[Synonym ]:
ZD 4407
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-[(2S,4R)-tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl]-2-thienyl]thio]
2H-Indol-2-one,1,3-dihydro-1-methyl-5-[[4-(tetrahydro-4-hydroxy-2-methyl-2H-pyran-4-yl)-2-thienyl]thio]-,(2S-trans)
AZD 4407

Biological Activity

[Description]:

AZD 4407 is a potent 5-lipoxygenase inhibitor.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Research Areas >> Inflammation/Immunology

[Target]

5-lipoxygenase[1]


[In Vitro]

In view of the powerful spasmogenic actions of leukotrienes in vascular and bronchial tissue, drugs which block their biosynthesis by inhibiting 5-lipoxygenase may have therapeutic potential in a variety of inflammatory conditions including inflammatory arthropothies, asthma, psoriasis, and inflammatory bowel disease. One such compound is AZD 4407 (ZD4407)[1].

[References]

[1]. Jonathan Hutton, et al. Use of a Titanium Thienyl Anion and a Simple Procedure for Introducing a Thiol Group into Thiophene in the Development of a Manufacturing Route to the 5-Lipoxygenase Inhibitor ZD4407. Org Process Res Dev. 1997 Jan 15;1(1): 61–67.


[Related Small Molecules]

U73122 | Zileuton | ML355 | Nordihydroguaiaretic acid | Indirubin-3'-monoxime | Caffeic acid | marmesin | Malotilate | 4',5-Dihydroxyflavone | Enazadrem | LY 178002 | RWJ 63556 | S-2474 | 5-Lipoxygenase-In-1 | A-69412

Chemical & Physical Properties

[ Molecular Formula ]:
C19H21NO3S2

[ Molecular Weight ]:
375.50500

[ Exact Mass ]:
375.09600

[ PSA ]:
103.31000

[ LogP ]:
3.86970

[ Storage condition ]:
2-8℃

Related Compounds