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JZP 430

Names

[ CAS No. ]:
1672691-74-5

[ Name ]:
JZP 430

Biological Activity

[Description]:

JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL)[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL
Research Areas >> Metabolic Disease

[Target]

IC50: 44 nM (ABHD6, human)[1]


[References]

[1]. Patel JZ, et al. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem. 2015 Feb;10(2):253-65.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H26N4O3S

[ Molecular Weight ]:
354.47

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds