4H-Pyran-4-one,2,6-bis(4-methoxyphenyl)-

Names

[ Name ]:
4H-Pyran-4-one,2,6-bis(4-methoxyphenyl)-

[Synonym ]:
2,6-bis-(4-methoxy-phenyl)-pyran-4-one
4H-Pyran-4-one,2,6-bis(p-methoxyphenyl)
2,6-bis(4-methoxyphenyl)-4H-pyran-4-one
2.6-Bis-<4-methoxy-phenyl>-4-pyron
2,6-Bis-(4-methoxy-phenyl)-pyran-4-on
2,6-di-(4-methoxyphenyl)-4H-pyran-4-one
2.6-Di-<4-methoxy-phenyl>-4-pyron

Biological Activity

[Description]:

NSC81111 is a potent and orally active EGFR-TK inhibitor with an IC50 of 0.15 nM. NSC81111 has anticaner effects[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

IC50: 0.15 nM (EGFR-TK)[1]

[References]

[1]. Nattanan Jiwacharoenchai, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022 Feb 15;58:128524.

Chemical & Physical Properties

[ Density]:
1.218g/cm3

[ Boiling Point ]:
528.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₁₆O₄

[ Molecular Weight ]:
308.32800

[ Flash Point ]:
235.1ºC

[ Exact Mass ]:
308.10500

[ PSA ]:
48.67000

[ LogP ]:
3.99100

[ Vapour Pressure ]:
3.01E-11mmHg at 25°C

[ Index of Refraction ]:
1.597

4H-Pyran-4-one,2,6-bis(4-methoxyphenyl)-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds