10-Hydroxydecanoic acid

Names

[ Name ]:
10-Hydroxydecanoic acid

[Synonym ]:
10-hydroxy-decanoic acid
Decanoic acid, 10-hydroxy-
10-Hydroxy-decansaeure
10-hydroxycapric acid
10-Hydroxycapricacid
10-HYDROXY-DECYLIC ACID
EINECS 216-848-1
MFCD00010510
10-Hydroxydecanoic acid
Decanoic acid,10-hydroxy
9-Oxy-nonan-carbonsaeure-(1)
10-Hydroxy-caprinsaeure
10-hydroxy capric acid

Biological Activity

[Description]:

10-Hydroxydecanoic acid (NSC 15139) is a saturated fatty acid of 10-hydroxy-trans-2-decenoic acid from royal jelly, with anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Takahashi K, et al. Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages. Biomed Res. 2013 Aug;34(4):205-14.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
330.8±15.0 °C at 760 mmHg

[ Melting Point ]:
75-77 °C(lit.)

[ Molecular Formula ]:
C₁₀H₂₀O₃

[ Molecular Weight ]:
188.26

[ Flash Point ]:
168.1±16.9 °C

[ Exact Mass ]:
188.141251

[ PSA ]:
57.53000

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.466

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Polymerization of 10-hydroxydecanoic acid in benzene with polyethylene glycol-modified lipase. Ajima A, et al.

Biotechnol. Lett. 7(5) , 303-306, (1985)

Lipase-catalyzed synthesis of an epoxy-functionalized polyester from the suberin monomer cis-9,10-epoxy-18-hydroxyoctadecanoic acid.

Biomacromolecules 8(2) , 757-60, (2007)

Estrogenic activities of Fatty acids and a sterol isolated from royal jelly.

Evid. Based. Complement. Alternat. Med. 5(3) , 295-302, (2008)

We have previously reported that royal jelly (RJ) from honeybees (Apis mellifera) has weak estrogenic activity mediated by interaction with estrogen receptors that leads to changes in gene expression ...