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Vofopitant dihydrochloride

Names

[ CAS No. ]:
168266-51-1

[ Name ]:
Vofopitant dihydrochloride

[Synonym ]:
Vofopitant dihydrochloride (USAN)
Vofopitant hydrochloride
Vofopitant HCl

Biological Activity

[Description]:

Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

pKi: 9.5 (NK1, rat), 10.6 (NK1, human)[1]


[References]

[1]. Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53.

Chemical & Physical Properties

[ Boiling Point ]:
542.5ºC at 760mmHg

[ Molecular Formula ]:
C21H25Cl2F3N6O

[ Molecular Weight ]:
505.36400

[ Flash Point ]:
281.9ºC

[ Exact Mass ]:
504.14200

[ PSA ]:
82.09000

[ LogP ]:
5.59630

[ Vapour Pressure ]:
7.83E-12mmHg at 25°C

Related Compounds