Vofopitant
Names
[ CAS No. ]:
168266-90-8
[ Name ]:
Vofopitant
[Synonym ]:
N-((2-Methoxy-5-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl)methyl)-2-phenyl-3-piperidinamine
3-Piperidiamine,N-((2-methoxy-5-(5-(trifluoromethyl)-1H-tetrazol-1-yl)phenyl)-methyl)-2-phenyl-,(2S-cis)
3(S)-(2-methoxy-5-(5-trifluoromethyltetrazol-1-yl)phenylmethylamino)-2-(S)-phenylpiperidine
[3H]-Vofopitant
UNII-K08BK043YS
Vofopitant [INN]
[2-methoxy-5-(5-trifluoromethyltetrazol-1-yl)benzyl]-(2S-phenylpiperidin-3S-yl)-amine
(2S-cis)-N-[[2-methoxy-5-[5-(trifluoromethyl)-1H-tetrazol-1yl]phenyl]methyl]-2-phenyl-3-piperidinamine
Vofopitant
Biological Activity
[Description]:
[Related Catalog]:
[Target]
pKi: 10.6 (Human NK1 receptor), 9.5 (Rat NK1 receptor), 9.8 (Ferret NK1 receptor)[1]
[In Vitro]
[In Vivo]
[Kinase Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.39g/cm3
[ Boiling Point ]:
542.5ºC at 760 mmHg
[ Molecular Formula ]:
C21H23F3N6O
[ Molecular Weight ]:
432.44200
[ Flash Point ]:
281.9ºC
[ Exact Mass ]:
432.18900
[ PSA ]:
76.89000
[ LogP ]:
3.99230
[ Vapour Pressure ]:
7.83E-12mmHg at 25°C
[ Index of Refraction ]:
1.624