PAT-347

Names

[ CAS No. ]:
1689554-51-5

[ Name ]:
PAT-347

Biological Activity

[Description]:

PAT-347 is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Metabolic Disease

[References]

[1]. Chen Y, et al. Design, synthesis and anti-fibrosis evaluation of imidazo [1, 2–a] pyridine derivatives as potent ATX inhibitors[J]. Bioorganic & Medicinal Chemistry, 2021, 46: 116362.

[2]. Joncour A, et al. Discovery, structure–activity relationship, and binding mode of an imidazo [1, 2-a] pyridine series of autotaxin inhibitors[J]. Journal of Medicinal Chemistry, 2017, 60(17): 7371-7392.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H21ClF2N2O3S

[ Molecular Weight ]:
538.99

Related Compounds