I-191

Names

[ Name ]:
I-191

Biological Activity

[Description]:

I-191 is a protease-activated receptor 2 (PAR-2) signaling pathway inhibitor extracted from patent WO2015048245A1. I-191 inhibits PAR-2 activators such as SLIGKV, Trypsin, and Thrombin with IC50s of 0.0014 μM, 0.0023 μM, 0.32 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)

Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.0014 μM (SLIGKV), 0.0023 μM (Trypsin), 0.32 μM (Thrombin)[1]

[References]

[1]. Luc J. Farmer, et al. Imidazopyridazines useful as inhibitors of the par-2 signaling pathway. WO2015048245A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₆FN₅O₂

[ Molecular Weight ]:
423.48

I-191

Names

Biological Activity

Chemical & Physical Properties

Related Compounds