Cathepsin K inhibitor 3
Names
[ CAS No. ]:
1694638-70-4
[ Name ]:
Cathepsin K inhibitor 3
Biological Activity
[Description]:
Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1].
[Related Catalog]:
[Target]
cathepsin K:0.5 nM (IC50)
[In Vivo]
Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog[1]. The pharmacokinetic parameters of compound 23 Parameters Cl(mL/min/kg) T1/2(h) %F Rat 13 1 33 Dog 3.1 4.1 38 Rhesus 18.5 2.3 55
Chemical & Physical Properties
[ Molecular Formula ]:
C30H31FN4O4S
[ Molecular Weight ]:
562.65