Z-Pro-Pro-aldehyde-dimethyl acetal

Names

[ Name ]:
Z-Pro-Pro-aldehyde-dimethyl acetal

[Synonym ]:
Benzyl (2S)-2-{[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl}-1-pyrrolidinecarboxylate
1-Pyrrolidinecarboxylic acid, 2-[[(2S)-2-(dimethoxymethyl)-1-pyrrolidinyl]carbonyl]-, phenylmethyl ester, (2S)-

Biological Activity

[Description]:

Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

PREP:12 nM (IC50)

[References]

[1]. Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5.

[2]. Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
522.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₈N₂O₅

[ Molecular Weight ]:
376.447

[ Flash Point ]:
269.8±30.1 °C

[ Exact Mass ]:
376.199829

[ LogP ]:
1.33

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.554

Z-Pro-Pro-aldehyde-dimethyl acetal

Names

Biological Activity

Chemical & Physical Properties

Related Compounds