1,3-Propanediamine,N1-(2-chloroethyl)-N3-(6-chloro-2-methoxy-9-acridinyl)-, hydrochloride (1:2)

Names

[ Name ]:
1,3-Propanediamine,N1-(2-chloroethyl)-N3-(6-chloro-2-methoxy-9-acridinyl)-, hydrochloride (1:2)

[Synonym ]:
AMES MUTAGEN 191
ICR-191ACRIDINE
icr-191
MFCD00013320
ACRIDINE MUTAGEN ICR 191
icr-191a
ICR 191 ACRIDINE MUTAGEN DIHYDROCHLORIDE
ICR-191DIHYDROCHLORIDE
6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride
EINECS 241-129-4
ICR 191 ACRIDINE MUTAGEN
ACRIDINEICR191
icrdihydrochloride

Chemical & Physical Properties

[ Melting Point ]:
261-262ºC

[ Molecular Formula ]:
C₁₉H₂₃Cl₄N₃O

[ Molecular Weight ]:
451.21700

[ Exact Mass ]:
449.06000

[ PSA ]:
46.18000

[ LogP ]:
6.74830

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7678000

CHEMICAL NAME :: Acridine, 6-chloro-9-(3-((2-chloroethyl)amino)propyl)amino-2-me thoxy-, dihydrochloride

CAS REGISTRY NUMBER :: 17070-45-0

LAST UPDATED :: 199410

DATA ITEMS CITED :: 41

MOLECULAR FORMULA :: C19-H21-Cl2-N3-O.2Cl-H

MOLECULAR WEIGHT :: 451.25

WISWESSER LINE NOTATION :: T C666 BNJ EG IM3M2G LO1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD20 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Amphibian - frog Embryo

DOSE/DURATION :: 1 umol/L

REFERENCE :: JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 94,187,1978

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H330-H350

[ Precautionary Statements ]:
P201-P260-P264-P280-P284-P302 + P350

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
45-46-26/27/28

[ Safety Phrases ]:
53-36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 1

[ RTECS ]:
AR7678000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Toxicologic evaluation of Dichrostachys glomerata extract: subchronic study in rats and genotoxicity tests.

Food Chem. Toxicol. 69 , 120-31, (2014)

In western Cameroon, edible fruits and seeds from the plant Dichrostachys glomerata are commonly used as spices. Extract from the fruit pods has been reported as a good natural source of antioxidants ...

Genotoxicity of rice bran oil extracted by supercritical CO2 extraction.

Biol. Pharm. Bull. 37(12) , 1963-70, (2014)

Rice bran oil extracted by supercritical CO2 extraction (RB-SCE) reportedly exhibits pharmacological activities such as antioxidant and in vivo hair growth-inducing effects. Such activities raise the ...

Attenuation of acridine mutagen ICR-191--DNA interactions and DNA damage by the mutagen interceptor chlorophyllin.

Biophys. Chem. 135(1-3) , 69-75, (2008)

We have investigated the ability of chlorophyllin (CHL) to interact with acridine mutagen ICR-191 (2-methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino)acridine) and also its ability to decrease bi...