ARTD10/PARP10-IN-1

Names

[ Name ]:
ARTD10/PARP10-IN-1

Biological Activity

[Description]:

ARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC50s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PARP

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

ARTD1/PARP1:4.4 μM (IC50)

ARTD10/PARP10:0.8 μM (IC50)

ARTD8/PARP14:1.6 μM (IC50)

ARTD7/PARP15:1.7 μM (IC50)

[References]

[1]. Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₂N₂O₄

[ Molecular Weight ]:
248.23

ARTD10/PARP10-IN-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds