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ACY-1083

Names

[ CAS No. ]:
1708113-43-2

[ Name ]:
ACY-1083

Biological Activity

[Description]:

ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC50 of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC6:3 nM (IC50)


[References]

[1]. Krukowski K, et al. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain. 2017 Jun;158(6):1126-1137.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H18F2N4O2

[ Molecular Weight ]:
348.35

[ Storage condition ]:
2-8℃

Related Compounds