(RS)-APICA

Names

[ Name ]:
(RS)-APICA

[Synonym ]:
1-Amino-5-phosphono-1-indanecarboxylic acid
1H-Indene-1-carboxylic acid, 1-amino-2,3-dihydro-5-phosphono-
1-Amino-5-phosphonoindane-1-carboxylic acid

Biological Activity

[Description]:

APICA is a potent CB1 and CB2 receptors agonist with EC50 values of 118 nM and 37 nM against CB1 and CB2 receptors, respectively. APICA possess cannabimimetic activity in vivo[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

hCB2-R:37 nM (EC50)

hCB1-R:118 nM (EC50)

[References]

[1]. Longworth M, et al. Synthesis and Pharmacological Profiling of the Metabolites of Synthetic Cannabinoid Drugs APICA, STS-135, ADB-PINACA, and 5F-ADB-PINACA. ACS Chem Neurosci. 2017 Aug 16;8(8):1673-1680.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
559.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂NO₅P

[ Molecular Weight ]:
257.18

[ Flash Point ]:
292.4±32.9 °C

[ Exact Mass ]:
257.045319

[ LogP ]:
-0.89

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.671

(RS)-APICA

Names

Biological Activity

Chemical & Physical Properties

Related Compounds