Propargyl-PEG3-phosphonic acid

Names

[ CAS No. ]:
1714139-62-4

[ Name ]:
Propargyl-PEG3-phosphonic acid

Biological Activity

[Description]:

Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Thorsten Heidelberg, et al. Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof. WO2015065168A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₇O₆P

[ Molecular Weight ]:
252.20

Propargyl-PEG3-phosphonic acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds