MI 14

Names

[ CAS No. ]:
1715934-43-2

[ Name ]:
MI 14

[Synonym ]:
N-[2-({6-Chloro-3-[3-(dimethylsulfamoyl)phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl}amino)ethyl]acetamide
MFCD29081194
N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
Acetamide, N-[2-[[6-chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]-

Biological Activity

[Description]:

MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection
Signaling Pathways >> PI3K/Akt/mTOR >> PI4K

[Target]

PI4KIIIβ:54 nM (IC50)

PI4KIIIα:>100 μM (IC50)

PI4KIIα:>100 μM (IC50)


[In Vitro]

MI 14 (化合物 36t) 对 HeLa 细胞中的 HCV 1b (EC50=0.087 µM)、CVB3 (EC50=0.145 µM)、HRVM (EC50=1.03 µM)、HVC 2a (EC50=10.6 µM) 具有抗病毒活性[1]。 MI 14 对磷脂酰肌醇 3 激酶 (PI3Ka、PI3Kb、PI3Kd 和 PI3Kg) 没有抑制作用，IC50 高达 10 µM[1]。

[References]

[1]. Ivana Mejdrová, et al. Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action. J Med Chem. 2015 May 14;58(9):3767-93.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C19H23ClN6O3S

[ Molecular Weight ]:
450.94

[ Exact Mass ]:
450.124084

[ LogP ]:
1.97

[ Index of Refraction ]:
1.661

Related Compounds