<Suppliers Price>

Varespladib

Names

[ CAS No. ]:
172732-68-2

[ Name ]:
Varespladib

[Synonym ]:
Acetic acid, 2-[[3-(2-amino-1,2-dioxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]-
({3-[Amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid
Varespladib
N-(3,4-dimethoxyphenyl)-6,7-dimethoxyquinazolin-4-amine

Biological Activity

[Description]:

LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (sPLA) inhibitor with IC50 of 7 nM.IC50 value: 7 nMTarget: sPLA2in vitro: LY315920 exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50 of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively. [2] In BAL cells challenged with human sPLA2, LY315920 at doses ranging from 0.1 μM–3 μM reduces the formation of thromboxane mediated by human sPLA2 in a concentration-dependent manner with an IC50 of approximately 0.8 μM. [2] In human conjunctival epithelial cell line (HCjE), LY315920 (10 μM) significantly inhibits all-trans-retinoic acid (RA) -induced membrane-associated mucin MUC16 expression by 100% at 24 hours and 99% at 48 hours. [3]in vivo: Ex vivo, LY315920 at doses ranging from 3 mg/kg to 30 mg/kg via i.v. inhibits human sPLA2-induced release of thromboxane from guinea pig BAL cells with ED50 of 16.1 mg/kg. [2] In Transgenic Mice Expressing Human sPLA2, both oral and i.v. administration of LY315920 (0.3 mg/kg–3 mg/kg) abolishes serum sPLA2 activity in a dose and time dependent manner. [2]

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Research Areas >> Inflammation/Immunology

[References]

[1]. Draheim SE, et al. Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides. J Med Chem. 1996 Dec 20;39(26):5159-75.

[2]. Snyder DW, et al. Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1999 Mar;288(3):1117-24.

[3]. Hori Y, et al. Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.


[Related Small Molecules]

U73122 | D609 | Darapladib | Quinacrine (dihydrochloride) | FIPI | Melittin | CAY10650 | AA26-9 | ML348 | Tanshinone I | Methyl Arachidonyl Fluorophosphonate | ML 349 | 1-Monolinolein | Lp-PLA2 -IN-1 | SPK-601

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
667.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H20N2O5

[ Molecular Weight ]:
380.394

[ Flash Point ]:
357.7±34.3 °C

[ Exact Mass ]:
380.137207

[ PSA ]:
111.62000

[ LogP ]:
2.45

[ Appearance of Characters ]:
white solid

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.630

[ Storage condition ]:
-20℃

Safety Information

[ RIDADR ]:
NONH for all modes of transport


Related Compounds