Human PTHrP-(1-36)

Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism[1][3].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Human PTHrP-(1-36) (EC50: 0.05 nM) increases intracellular calcium in human epidermal keratinocytes[2]. Human PTHrP-(1-36) (100 nM, 24 h) increases human β-cell proliferation[3]. Human PTHrP-(1-36) (100 nM, 30 min) enhances insulin secretion in human islets[3]. PTHrP-(1-36) (mouse, EC50: 1 nM) induces a rapid Ca2+ response in UMR 106 cells[4].

PTHrP-(1-36) (mouse, 160 μg/kg, s.c., for 5 days/week for 7, 30, or 90 days) enhances beta cell regeneration and increases beta cell mass in a mouse model of partial pancreatectomy[5]. PTHrP-(1-36) (mouse, 100 μg/kg, s.c., every other day) reverses the observed decrease of Wisp1 expression in the diabetic mice[6].