a2e

Names

[ CAS No. ]:
173449-96-2

[ Name ]:
a2e

[Synonym ]:
N-retinylidene-N-retinyl-ethanolamine
2-[2,6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E,7E-octatetraenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E-hexatrienyl]pyridinium
N-retinyl-N-retinylidene ethanolamine
2-[2,6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E,7E-octatetraenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E-hexatrienyl]-pyridinium
(2-[2,6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E,7E-octatetraenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E-hexatrienyl]-pyridinium)
N-retinylidene-N-retinylethanolamine
2-[(1E,3E,5E,7E)-2,6-Dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-1,3,5,7-tetraenyl]-1-(2-hydroxy-ethyl)-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-pyridinium

Biological Activity

[Description]:

Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Jeong SY, et al. Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells. Food Chem Toxicol. 2019 Sep;131:110555.  

[2]. S. Ben-Shabat, et al; Elucidating the Role of Pyridinium bis-Retinoid(A2E) in Retinal Pigment Epithelium (RPE) Cell Damages. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2201.

Chemical & Physical Properties

[ Molecular Formula ]:
C42H58NO+

[ Molecular Weight ]:
592.91600

[ Exact Mass ]:
592.45200

[ PSA ]:
24.11000

[ LogP ]:
10.99730

Related Compounds