Tyrosylleucine

Names

[ Name ]:
Tyrosylleucine

[Synonym ]:
N-L-Tyrosyl-L-leucin
TYR-LEU
L-Leucine,N-L-tyrosyl
N-L-tyrosyl-L-leucine
tyrosylleucine
L-Tyrosyl-L-leucine
L-Tyrosyl-L-leucin
H-TYR-LEU-OH
L-tyrosine-L-leucine
TYR-LEU CRYSTALLINE

Biological Activity

[Description]:

Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice[1]. Animal Model: Male ddY mice (24-27 g)[1] Dosage: 0.1-30 mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100 mg/kg, p.o. Administration: Administered orally, intracerebroventricularly, or intraperitoneally Result: Decreased immobility time after intraperitoneal (1-30 mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST. Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice.

[References]

[1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257.

[2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.

Chemical & Physical Properties

[ Density]:
1.218g/cm3

[ Boiling Point ]:
575.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₂N₂O₄

[ Molecular Weight ]:
294.35

[ Flash Point ]:
302.1ºC

[ Exact Mass ]:
294.15800

[ PSA ]:
112.65000

[ LogP ]:
1.96870

[ Vapour Pressure ]:
4.2E-14mmHg at 25°C

[ Index of Refraction ]:
1.565

Safety Information

[ WGK Germany ]:
3

[ HS Code ]:
2924299090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%