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SDZ285428

Names

[ CAS No. ]:
174262-13-6

[ Name ]:
SDZ285428

[Synonym ]:
4'-chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]biphenyl-4-carboxamide
4'-Chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]-4-biphenylcarboxamide
[1,1'-Biphenyl]-4-carboxamide, 4'-chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]-

Biological Activity

[Description]:

SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Signaling Pathways >> Anti-infection >> Fungal

[Target]

CYP51


[In Vivo]

Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases[1].

[References]

[1]. Lepesheva GI, et al. CYP51: A major drug target in the cytochrome P450 superfamily. Lipids. 2008 Dec;43(12):1117-25.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
651.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H20ClN3O

[ Molecular Weight ]:
401.888

[ Flash Point ]:
347.7±31.5 °C

[ Exact Mass ]:
401.129486

[ LogP ]:
4.54

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.634

[ Storage condition ]:
-20℃

Related Compounds