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Amino-Tri-(carboxyethoxymethyl)-methane

Names

[ CAS No. ]:
174362-95-9

[ Name ]:
Amino-Tri-(carboxyethoxymethyl)-methane

Biological Activity

[Description]:

Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Markus Ribbert, et al. Self coupling recombinant antibody fusion proteins. WO2009013359A2.

[2]. David Margulies, et al. Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof. WO2015166491A2.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H23NO9

[ Molecular Weight ]:
337.32

[ Storage condition ]:
2-8°C

Related Compounds