5-Chloro-6-hydroxy-1,3-benzoxazol-2(3H)-one

Names

[ Name ]:
5-Chloro-6-hydroxy-1,3-benzoxazol-2(3H)-one

[Synonym ]:
5-chloro-6-hydroxy-3H-1,3-benzoxazol-2-one
2(3H)-Benzoxazolone, 5-chloro-6-hydroxy-
5-Chloro-6-hydroxy-1,3-benzoxazol-2(3H)-one

Biological Activity

[Description]:

6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Elbarbry F, et al. Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities. Pharmacogn Mag. 2018 Jan;13(Suppl 4):S895-S899.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Melting Point ]:
240-242ºC

[ Molecular Formula ]:
C₇H₄ClNO₃

[ Molecular Weight ]:
185.565

[ Exact Mass ]:
184.987976

[ PSA ]:
66.23000

[ LogP ]:
1.59

[ Index of Refraction ]:
1.651

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
methanol: soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM5260000

CHEMICAL NAME :: 2-Benzoxazolinone, 5-chloro-6-hydroxy-

CAS REGISTRY NUMBER :: 1750-45-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H4-Cl-N-O3

MOLECULAR WEIGHT :: 185.57

WISWESSER LINE NOTATION :: T56 BMVOJ GQ HG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),340,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(1),340,1964

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
DM5260000

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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