Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane
Names
[ CAS No. ]:
175724-30-8
[ Name ]:
Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane
[Synonym ]:
tert-butyl 3-[2-amino-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]-2-[[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]methyl]propoxy]propanoate
Biological Activity
[Description]:
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[Related Catalog]:
[Target]
PEGs
Cleavable
[In Vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C25H47NO9
[ Molecular Weight ]:
505.64200
[ Exact Mass ]:
505.32500
[ PSA ]:
132.61000
[ LogP ]:
3.62940