Xeglyze

Names

[ Name ]:
Xeglyze

[Synonym ]:
5,5'-Dimethyl-2,2'-bipyridyl
5,5′-dimethyl-2,2′-bipyridine
5,5'-dimethyl-bpy
5,5'-Dimethyl-2,2'-dipyridyl
5,5'-dimethyl-2,2'-bipy
6,6'-Di-3-picoline
MFCD01740554
5,5'-dimethyl-2,2'-bispyridine
Xeglyze
2,2'-BIPYRIDINE,5,5'-DIMETHYL
6,6'-Di-3-picolyl
5,5'-Dimethyl-2,2'-bipyridine
2,2'-Bipyridine, 5,5'-dimethyl-
abametapir

Biological Activity

[Description]:

Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[In Vitro]

Abametapir is capable of chelating heavy metal ions, including iron, copper, and zinc, and is therefore able to interact with a range of targets within the insect that require metal co-factors for function, including metalloproteinases[2].

[References]

[1]. Vernon Morrison Bowles, et al. Effect of a New Head Lice Treatment, Abametapir Lotion, 0.74%, on Louse Eggs: A Randomized, Double-Blind Study. Glob Pediatr Health. 2019; 6: 2333794X19831295.

[2]. Vernon M. Bowles, et al. Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae). J Med Entomol. 2017 Jan; 54(1): 167-172.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
315.7±37.0 °C at 760 mmHg

[ Melting Point ]:
114-117 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₂N₂

[ Molecular Weight ]:
184.237

[ Flash Point ]:
119.3±18.1 °C

[ Exact Mass ]:
184.100052

[ PSA ]:
25.78000

[ LogP ]:
2.20

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.566

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW1766000

CHEMICAL NAME :: 2,2'-Bipyridine, 5,5'-dimethyl-

CAS REGISTRY NUMBER :: 1762-34-1

BEILSTEIN REFERENCE NO. :: 0123183

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H12-N2

MOLECULAR WEIGHT :: 184.26

WISWESSER LINE NOTATION :: T6NJ E1 B- BT6NTJ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,815,1985

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DW1766000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis, characterization and crystal structure determination of iron (III) hetero-ligand complexes containing 2, 2'-bipyridine, 5, 5'-dimethyl-2, 2'-bipyridine and chloride, [Fe(bipy)Cl₄][bipy·H] and [Fe(dmbipy)₂Cl₂][FeCl₄]. Amani V, et al.

Polyhedron 26(15) , 4257-4262, (2007)