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(RS)-3,4-DCPG

Names

[ CAS No. ]:
176796-64-8

[ Name ]:
(RS)-3,4-DCPG

[Synonym ]:
pacap 1-27
hms3267f06

Biological Activity

[Description]:

(R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. (R,S)-3,4-Dicarboxyphenylglycine antagonizes AMPA-mediated depolarization of motor neurons in neonatal rats. (R,S)-3,4-Dicarboxyphenylglycine can be used in the study of neurological diseases[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

AMPA[1].


[References]

[1]. Thomas NK, et al. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur J Pharmacol. 1997 Nov 5;338(2):111-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H9NO6

[ Molecular Weight ]:
239.18

[ Exact Mass ]:
239.04300

[ PSA ]:
137.92000

[ LogP ]:
0.86770

Related Compounds