S-17092

Names

[ Name ]:
S-17092

[Synonym ]:
S-17092

Biological Activity

[Description]:

S 17092 (S 17092-1) is a potent cerebral prolyl-endopeptidase (PEP) inhibitor with an IC50 of 1.2 nM. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Philippe Morain, et al. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies. CNS Drug Rev. Spring 2002;8(1):31-52.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₈N₂O₂S

[ Molecular Weight ]:
384.53500

[ Exact Mass ]:
384.18700

[ PSA ]:
65.92000

[ LogP ]:
3.35850

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Articles

Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Kim JD, Toda C, D'Agostino G, et al.

Proc. Natl. Acad. Sci. U. S. A. 111(32) , 11876-81, (2014)