6-nitro-2-(4-nitrophenyl)-1H-benzimidazole

Names

[ Name ]:
6-nitro-2-(4-nitrophenyl)-1H-benzimidazole

[Synonym ]:
5-nitro-2-(4-nitro-phenyl)-1(3)H-benzimidazole
5-nitro-2-(4-nitro-phenyl)-1(3)H-benzoimidazole
5-Nitro-2-(4-nitro-phenyl)-1H-benzoimidazole
2-(4-nitrophenyl)-5-nitro-1H-benzimidazole
5-Nitro-2-(4-nitro-phenyl)-1(3)H-benzimidazol
5-nitro-2-(4-nitrophenyl)-1H-benzo[d]imidazole
2-(4-nitrophenyl)-5-nitrobenzimidazole
5-nitro-2-(4-nitrophenyl)-1H-benzimidazole

Biological Activity

[Description]:

MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-2:4.2 ± 0.2 μM (IC50)

MMP13:12 ± 7 μM (IC50)

MMP-9:23.3 ± 10. μM (IC50)

MMP-8:25 ± 10 μM (IC50)

[References]

[1]. Laghezza A, et al. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorg Med Chem. 2020 Feb 1;28(3):115257.

Chemical & Physical Properties

[ Density]:
1.544g/cm3

[ Boiling Point ]:
565.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₈N₄O₄

[ Molecular Weight ]:
284.22700

[ Flash Point ]:
295.6ºC

[ Exact Mass ]:
284.05500

[ PSA ]:
120.32000

[ LogP ]:
4.09270

[ Vapour Pressure ]:
8.54E-13mmHg at 25°C

[ Index of Refraction ]:
1.74

Safety Information

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%