Flavokawain B

Names

[ Name ]:
Flavokawain B

[Synonym ]:
(E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
CARDAMONIN-4'-METHYL ETHER
2'-Hydroxy-4',6'-dimethoxychalcone
2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (2E)-
flavokawin B
(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one
(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-phenylprop-2-en-1-one
1OR CQ EO1 BV1U1R &&E Form
MFCD00075877
DIMETHOXY-2'-HYDROXYCHALCONE,4',6'
Flavokawain B
Flavokavain B

Biological Activity

[Description]:

Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Rossette MC, et al. The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B. Phytother Res. 2017 Oct;31(10):1607-1613.

[2]. Li X, et al. Flavokawain B targets protein neddylation for enhancing the anti-prostate cancer effect of Bortezomib via Skp2 degradation. Cell Commun Signal. 2019 Mar 18;17(1):25.

Chemical & Physical Properties

[ Density]:
1.203±0.06 g/cm3

[ Boiling Point ]:
500.1±50.0 °C at 760 mmHg

[ Melting Point ]:
178-179 ºC (ethanol )

[ Molecular Formula ]:
C₁₇H₁₆O₄

[ Molecular Weight ]:
284.306

[ Flash Point ]:
185.8±23.6 °C

[ Exact Mass ]:
284.104858

[ PSA ]:
55.76000

[ LogP ]:
4.01

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.614

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Practically insoluble (0.012 g/L) (25 ºC)

Safety Information

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%