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PSN 375963 hydrochloride

Names

[ CAS No. ]:
1781834-82-9

[ Name ]:
PSN 375963 hydrochloride

Biological Activity

[Description]:

PSN 375963 hydrochloride is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 hydrochloride shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> GPR119

[References]

[1]. Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175.

[2]. Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H24ClN3O

[ Molecular Weight ]:
321.84

Related Compounds