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Revaprazan Hydrochloride

Names

[ CAS No. ]:
178307-42-1

[ Name ]:
Revaprazan Hydrochloride

[Synonym ]:
T66 CNT&J B1 C- DT6N CNJ BMR DF& E1 F1 &&HCl
N-(4-Fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-2(1H)-isoquinolinyl)-2-pyrimidinamine hydrochloride (1:1)
4-(3,4-Dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-2-pyrimidinamine, monohydrochloride
N-(4-Fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)pyrimidin-2-amine hydrochloride
Revanex
2-Pyrimidinamine, 4-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-, monohydrochloride
Revaprazan HCL
2-Pyrimidinamine, 4-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-, hydrochloride (1:1)
YH1885

Biological Activity

[Description]:

Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Immunology/Inflammation >> COX
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Acid pump; COX-2[1]


[References]

[1]. Lee JS, et al. Revaprazan, a novel acid pump antagonist, exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling. J Clin Biochem Nutr. 2012 Sep;51(2):77-83.

Chemical & Physical Properties

[ Melting Point ]:
205-208°

[ Molecular Formula ]:
C22H24ClFN4

[ Molecular Weight ]:
398.904

[ Exact Mass ]:
398.167358

[ PSA ]:
41.05000

[ LogP ]:
6.03980

[ Storage condition ]:
2-8°C

Related Compounds