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NGD 94-1

Names

[ CAS No. ]:
178928-68-2

[ Name ]:
NGD 94-1

Biological Activity

[Description]:

NGD94-1 is a specific dopamine D4 receptor antagonist. NGD94-1 can effectively reverse Phencyclidine-induced cognitive impairment in marmosets. NGD94-1 can be used in the study of psychiatric diseases[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[References]

[1]. Jentsch JD, et al. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology (Berl). 1999 Feb;142(1):78-84.  

Chemical & Physical Properties

[ Density]:
1.259g/cm3

[ Boiling Point ]:
578.2ºC at 760mmHg

[ Molecular Formula ]:
C18H20N6

[ Molecular Weight ]:
320.39

[ Flash Point ]:
303.5ºC

[ Exact Mass ]:
320.17500

[ PSA ]:
60.94000

[ LogP ]:
2.19180

[ Vapour Pressure ]:
2.3E-13mmHg at 25°C

[ Index of Refraction ]:
1.647

Related Compounds