GW284543 hydrochloride

Names

[ Name ]:
GW284543 hydrochloride

Biological Activity

[Description]:

GW284543 (UNC10225170) hydrochloride is a selective MEK5 inhibitor. GW284543 reduces pERK5, and decreases endogenous MYC protein[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> MEK

[Target]

MEK5

[In Vitro]

GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5[1]. Western Blot Analysis[1] Cell Line: MIA PaCa-2 cells Concentration: 10 and 20 μM Incubation Time: 6 hours Result: Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.

[References]

[1]. Vaseva AV, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 2018 Nov 12;34(5):807-822.e7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₁ClN₂O₃

[ Molecular Weight ]:
408.88

[ Storage condition ]:
Sealed in dry,Room Temperature

GW284543 hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds