EGFR/ErbB-2/ErbB-4 inhibitor-2

Names

[ CAS No. ]:
179248-61-4

[ Name ]:
EGFR/ErbB-2/ErbB-4 inhibitor-2

[Synonym ]:
HMS3229C21
4557W
IN1350
EGFR/ErbB-2 Inhibitor

[Description]:

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:0.017 μM (IC50)

ErbB2:0.08 μM (IC50)

ErbB4:1.91 μM (IC50)

[In Vitro]

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively[1].

[References]

[ Molecular Formula ]:
C₂₃H₂₁N₃O₃

[ Molecular Weight ]:
387.43100

[ Exact Mass ]:
387.15800

[ PSA ]:
65.50000

[ LogP ]:
5.04260