22-alpha-Hydroxy Cholesterol

Names

[ Name ]:
22-alpha-Hydroxy Cholesterol

[Synonym ]:
Narthesterol
22BF-HYDROXYCHOLESTEROL
22(S)-hydroxycholesterol
(3β,22S)-Cholest-5-ene-3,22-diol
22BETA-HYDROXYCHOLESTEROL
Cholest-5-ene-3,22-diol, (3β,22S)-
22R-OHC
22(R)-HYDROXYCHOLESTEROL

Biological Activity

[Description]:

22(R)-Hydroxycholesterol (Narthesterol) is an endogenous LXR agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> LXR

Research Areas >> Metabolic Disease

[References]

[1]. Costet P, et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000 Sep 8;275(36):28240-5.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
513.1±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₄₆O₂

[ Molecular Weight ]:
402.65

[ Flash Point ]:
213.5±17.2 °C

[ Exact Mass ]:
402.349792

[ PSA ]:
40.46000

[ LogP ]:
7.66

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.536

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.

Gynecol. Oncol. 135(2) , 333-41, (2014)

Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxys...

HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells.

Toxicol. Appl. Pharmacol. 282(1) , 20-9, (2015)

Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD distu...

Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout.

Biol. Reprod. 86(1) , 1-12, (2012)

In fish, like in other vertebrates, luteinizing hormone (Lh) is an essential hormone for the completion of oocyte maturation. In salmonid fish (i.e., salmon and trout), oocyte maturation is induced by...