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Tyk2-IN-5

Names

[ CAS No. ]:
1797432-62-2

[ Name ]:
Tyk2-IN-5

Biological Activity

[Description]:

Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Inflammation/Immunology

[Target]

Tyk2 JH2:0.086 nM (Ki)

IFNα:25 nM (IC50)


[References]

[1]. Liu C, et al. Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors. ACS Med Chem Lett. 2019 Feb 21;10(3):383-388.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H19FN8O2

[ Molecular Weight ]:
434.43

Related Compounds