BAY-588

Names

[ Name ]:
BAY-588

[Synonym ]:
BAY-588
2,4-Quinolinedicarboxamide, N4-[1-[[4-(1,1-dimethylethyl)phenyl]methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-
7-Fluoro-N4-{5-methyl-1-[4-(2-methyl-2-propanyl)benzyl]-3-(trifluoromethyl)-1H-pyrazol-4-yl}-2,4-quinolinedicarboxamide
N4-[1-[[4-(1,1-Dimethylethyl)phenyl]methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide

Biological Activity

[Description]:

BAY-588 is a selective inhibitor of GLUT1 with an IC50 value of 1.18μM[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

IC50=1.18μM（GLUT1)[1], IC50>10μM（GLUT2)[1], IC50=5.47μM（GLUT3)[1], IC50=0.5μM（GLUT4)[1]

[References]

[1]. Holger Siebeneicher, et, al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016, 11, 20.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
603.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₅F₄N₅O₂

[ Molecular Weight ]:
527.51

[ Flash Point ]:
318.9±31.5 °C

[ Exact Mass ]:
527.194458

[ LogP ]:
6.14

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.604

BAY-588

Names

Biological Activity

Chemical & Physical Properties

Related Compounds