<Suppliers Price>

HIF-2α-IN-1

Names

[ CAS No. ]:
1799948-06-3

[ Name ]:
HIF-2α-IN-1

[Synonym ]:
Benzonitrile, 3-[[(3R)-4-(difluoromethyl)-2,2-difluoro-2,3-dihydro-3-hydroxy-1,1-dioxidobenzo[b]thien-5-yl]oxy]-5-fluoro-
3-{[(3R)-4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile

Biological Activity

[Description]:

HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay.IC50 value: ＜ 500 nMTarget: HIF-2α

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Research Areas >> Metabolic Disease

[References]

[1]. Bruick Richard Keith, et al. HIF-2α inhibitors for treating iron overload disorders. From PCT Int. Appl. (2016), WO 2016057242 A1 20160414.

[2]. Dixon Darryl David, et al. Preparation of cyclic sulfone and sulfoximine analogs as HIF-2α inhibitors. From PCT Int. Appl. (2015), WO 2015095048 A1 20150625.


[Related Small Molecules]

Dimethyloxalylglycine | PT-2385 | FG-4592 | PX-478 2HCl | BAY 87-2243 | Vadadustat | Daprodustat | Oltipraz | Chlorogenic acid | LW 6 | Molidustat | IOX2 | Paeoniflorin | KC7F2 | oroxylin A

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
499.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H8F5NO4S

[ Molecular Weight ]:
405.296

[ Flash Point ]:
256.1±28.7 °C

[ Exact Mass ]:
405.009430

[ LogP ]:
2.56

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8℃

Related Compounds