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HPB

Names

[ CAS No. ]:
1800066-24-3

[ Name ]:
HPB

[Synonym ]:
N-Hydroxy-4-{[(2-hydroxyethyl)(phenylacetyl)amino]methyl}benzamide
N-Hydroxy-4-((N-(2-hydroxyethyl)-2-phenylacetamido)methyl)benzamide
HPB
Benzeneacetamide, N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-N-(2-hydroxyethyl)-

Biological Activity

[Description]:

HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC6:31 nM (IC50)

HDAC1:1130 nM (IC50)


[References]

[1]. Nicholas J Porter, et al. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13459-13464.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C18H20N2O4

[ Molecular Weight ]:
328.362

[ Exact Mass ]:
328.142303

[ LogP ]:
0.64

[ Index of Refraction ]:
1.622

Related Compounds