CDK4/6-IN-2

Names

[ CAS No. ]:
1800506-48-2

[ Name ]:
CDK4/6-IN-2

Biological Activity

[Description]:

CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK4:2.7 nM (IC50)

CDK6:16 nM (IC50)


[In Vitro]

CDK4/6-IN-2 inhibits H358, H441, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells with IC50s of 290.9, 147.8, 260.5, 139, 36.98, 162.5, and 316.4 nM, respectively[1].

[References]

[1]. Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H32F2N8

[ Molecular Weight ]:
506.59

Related Compounds