(4E)-TCO-PEG4-DBCO

Names

[ CAS No. ]:
1801863-88-6

[ Name ]:
(4E)-TCO-PEG4-DBCO

Biological Activity

[Description]:

TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Rahim MK, et al. Enhancing reactivity for bioorthogonal pretargeting by unmasking antibody-conjugated trans-cyclooctenes. Bioconjug Chem. 2015 Feb 18;26(2):352-60.

Chemical & Physical Properties

[ Molecular Formula ]:
C38H49N3O8

[ Molecular Weight ]:
675.81

[ Storage condition ]:
-20°C