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ABBV-318

Names

[ CAS No. ]:
1802848-94-7

[ Name ]:
ABBV-318

Biological Activity

[Description]:

ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease

[Target]

hNav1.7:2.8 μM (IC50)

hNav1.8:3.3 μM (IC50)


[References]

[1]. Patel MV, et, al. Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:116743.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H15F4N3O2

[ Molecular Weight ]:
405.35

Related Compounds