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Methyltetrazine-PEG4-maleimide

Names

[ CAS No. ]:
1802908-02-6

[ Name ]:
Methyltetrazine-PEG4-maleimide

[Synonym ]:
Methyltetrazine-PEG4-maleimide
1H-Pyrrole-1-butanamide, 2,5-dihydro-N-[17-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]-15-oxo-3,6,9,12-tetraoxa-16-azaheptadec-1-yl]-2,5-dioxo-
20-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl]-17-oxo-4,7,10,13-tetraoxa-16-azaicosan-1-amide
MFCD28053555
Tetrazine-PEG4-maleimide

Biological Activity

[Description]:

Methyltetrazine-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C24H30N6O7

[ Molecular Weight ]:
613.662

[ Exact Mass ]:
613.286011

[ LogP ]:
-2.38

[ Index of Refraction ]:
1.556

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/38

[ Safety Phrases ]:
26

Related Compounds